Calcium levels fall in pregnancy from dilution and this leads to increased vitamin D production, which means that more calcium is absorbed from the gut. Hypercalciuria therefore results.
The increased calcium levels lead to suppression of PTH.
For unclear reasons, PTHrP levels also increase, and this further suppresses PTH. The PTHrp comes from breast. It is also made in the placenta, decidua, amnion, fetal parathyroid glands and umbilical cord but fetal PTHrP has been shown not to cross the placenta.
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